Mathematical modeling and simulation of ventricular
activation sequences: implications for cardiac
full text from the publisher (open access)
Next to clinical and experimental research, mathematical modeling plays a crucial role in medicine. Biomedical research takes place on many different levels, from molecules to the whole organism. Due to the complexity of biological systems the interactions between components are often difficult or impossible to understand without the help of mathematical models. Mathematical models of cardiac electrophysiology have made a tremendous progress since the first numerical ECG simulations in the 1960s. This paper briefly reviews the development of this field, and discusses some example cases where models have helped us forward, emphasizing applications that are relevant for the study of heart failure and cardiac resynchronization therapy.
contextThis review paper appeared in a special issue entitled "Pathobiology of Cardiac Dyssynchrony".
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