Some features of our model are
- Anatomy obtained from CT scans as described by
Lorange and Gulrajani in 1993, but ...
- we are presently using a refined finite-difference
grid with 0.2-mm resolution...
- which results in 25 million to 60 million nodes...
- consuming 12 GB of computer memory for a monodomain, and
60 GB for a bidomain simulation.
- The Purkinje system is modeled using early activation times
obtained from the human heart studies of
et al 1970
- Several membrane models are interfaced to our model, such
as those by
Bernus and by
- The bidomain equations are solved using a fully-explicit
integration of the membrane potential, and a BiCGSTAB
algorithm with ILU(0) preconditioning is used to solve
for the extracellular potential
- All this is currently done on 64 processors of an
SGI Altix 4700
computer at RQCHP,
which does a monodomain simulation of a single heart beat in 40 minutes
and a bidomain simulation in about 1 day.
- Our monodomain model is described in detail by
Trudel et al. IEEE Trans Biomed Eng 2004; recent improvements in
Potse, Dubé and Gulrajani, Conf IEEE-EMBS 2003
- We first reported on our bidomain model at the
31st International Congress on Electrocardiology
June/July 2004 in Kyoto, Japan. A more substantial paper
about this model was published in
IEEE Trans Biomed Eng 2006.
For more recent publications see
my list of papers.